To make scientific GUIs accessible to non-experts, consider the following:

- Intuitive design: Use clear and simple language, avoiding technical jargon.

- User-centered design: Involve non-experts in the design process to ensure the GUI meets their needs.

- Visualizations: Utilize interactive and dynamic visualizations to facilitate understanding.

- Guidance and tutorials: Provide comprehensive guidance, tutorials, and documentation.

- Simplified workflows: Streamline complex processes into straightforward, step-by-step procedures.

- Error handling: Implement intuitive error handling and feedback mechanisms.

- Customization: Allow customization to accommodate diverse user needs and skill levels.

- Collaboration tools: Incorporate collaboration features to facilitate expert support.

- Accessibility standards: Adhere to accessibility standards, such as WCAG 2.1, to ensure usability for all users.

- Testing and iteration: Conduct usability testing with non-experts and iterate on the design accordingly.

- Contextual help: Offer contextual help and tooltips to explain complex concepts and features.

- Minimal technical requirements: Ensure the GUI can run on a range of devices and systems.

By addressing these considerations, you can create a scientific GUI that is accessible and usable for non-experts, enabling a broader audience to engage with complex scientific data and research.