To support screen readers in a GUI design:

1. Use semantic HTML: Provide meaning to the structure of content using HTML elements like headings, paragraphs, and lists.

2. Add ARIA attributes: Use Accessible Rich Internet Applications (ARIA) attributes to enhance screen reader support for dynamic content.

3. Provide alternative text: Use alt text for images, icons, and graphics to help screen readers describe visual content.

4. Use clear and consistent labeling: Label elements like buttons, form fields, and links with clear and consistent text.

5. Implement keyboard navigation: Allow users to interact with the GUI using only their keyboard.

6. Test with screen readers: Verify compatibility with popular screen readers like JAWS, NVDA, and VoiceOver.

7. Use high contrast colors: Select colors with sufficient contrast between background and foreground elements.

8. Provide a logical reading order: Organize content in a logical order to facilitate smooth screen reader navigation.

9. Avoid using tables for layout: Use tables only for tabular data, as screen readers may struggle with table-based layouts.

10. Keep it simple: Avoid complex and cluttered interfaces that may confuse screen readers and users.

By incorporating these design considerations, you can create a GUI that is accessible and usable for screen reader users.