To optimize a GUI for notifications and quick interactions on wearable devices:

- Keep notifications brief and concise

- Use clear and intuitive icons and graphics

- Prioritize notifications by importance and relevance

- Use haptic feedback and audio cues to alert users

- Design for glanceability, allowing users to quickly scan information

- Use swipe gestures and simple taps for navigation

- Limit interaction depth, minimizing the number of taps required

- Implement quick actions and shortcuts for frequent tasks

- Use voice commands and dictation for hands-free interaction

- Consider using a notification shade or hub for easy access

- Ensure notifications are readable in various lighting conditions

- Test and refine notification timing and frequency

- Allow users to customize notification settings and preferences

- Integrate with other device features, like music or calendar apps

- Use wearable-specific features, like raise-to-wake or gesture recognition.

By following these guidelines, you can create a GUI that effectively handles notifications and quick interactions on wearable devices, providing a seamless user experience.